Technologists at the Sree Chitra Triunal Institute for Medical Sciences and Technology (SCTIMST), an autonomous institute under the Department of Science and Technology (DST), have developed two types of nasal and oral swabs and viral transport medium for COVID-19 testing.
Chitra EmBed flocked nylon swabs (co-developed with Mallelil Industries Pvt ltd), and Chitra EnMesh, polymeric foam-tipped, lint-free swabs with flexible plastic handles developed by technologists Dr Lynda V Thomas, Dr Shyni Velayudhan and Dr Maya Nandakumar from SCTIMST have both proven efficiency in the adequacy of specimen collection and rapid elution (extracting one material from another by washing with a solvent) of specimen into the liquid viral medium. They also have good recovery of viral RNA collected using these swabs and medium. The swabs will be available as sterile, ready-to-use devices.
The swabs are designed for efficiency and comfort in the working environment and help in improved specimen collection with minimum discomfort to patients. Their safe and convenient breakpoint ensures minimal contact with the health worker with the sample during packing.
The second innovation, Chitra Viral Transport Medium, is specifically designed to retain the virus in its active form during its transportation from the collection point to the laboratory. Currently, kits containing 50 (3ml/vial) viral transport medium with 50 swabs cost is upwards of Rs 12,000.
Technologies for both swabs and viral transport medium have been transferred to two industries for immediate manufacture and sales Mallelil Industries, Origin diagnostics, and Levram Life sciences.
Currently, nasal and throat specimens collected with specially designed swabs are used for the detection of SARS-COV2 by viral gene amplification method, which is necessary for the confirmation of COVID-19. Proper and adequate specimen collection and its transport in a suitable liquid medium are critical for ensuring good quality and quantity of viral RNA from the sample for testing, as these influence the accuracy of the test. Centre for disease control and prevention (CDC), the USA, recommends the use of synthetic fibre swabs with plastic shafts, preferably flocked swabs when available.
These two swabs developed with locally available material can reduce import dependency of the materials currently used and can meet the huge demand for them at much lower costs.
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